Archives of Pharmacal Research. 2012 Apr; 35(3): 6423180. doi: 10.1007/s12272-012-0311-8
Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge
Tae-Su Jang , HaiYan Zhang , GeumJin Kim , Dong Woo Kim , Byung-Sun Min , Wonku Kang , Seung Ho Lee , Kun Ho Son* , MinKyun Na*-
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상세조회 9건
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Abstract
Fatty acid synthase (FAS) is considered as a novel drug target for the development of anticancer and anti-obesity agents. Bioassay-guided fractionation of a n-hexane-soluble extract prepared from the roots of Salvia miltiorrhiza Bunge (Labiatae), using an in vitro enzyme assay, led to the isolation of five abietane diterpenoids: 15,16-dihydrotanshinone I (1), cryptotanshinone (2), tanshinone I (3), tanshinone IIA (4), and dansenspiroketallactone (5). Compounds 1–5 were tested for their in vitro FAS inhibitory activity and, except for compound 5 (IC₅₀ > 100 μM), compounds 1–4 inhibited the enzyme activity with IC₅₀ values ranging from 12.0 to 30.3 μM. Our findings may be partially related to the anticancer activity of abietane diterpenoids from the plant, suggesting a further study on the anticancer potential of tanshinone derivatives.
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