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  • 국내학술논문 (285,077)
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  • 1.
  • Background: Korea is experiencing a population decline and rapid aging. The life expectancy of women is greater than that of men, but these extra years generally do not involve good health for women. This study aimed to develop a differentiated physical activity program based on local community health promotion for elderly women and to evaluate the program’s effectiveness.
    Methods/results: The participants were divided into an exercise group (n = 57) and a control group (n = 52). The exercise group underwent a regular physical activity intervention program 3 times a week for 12 weeks. We compared changes in anthropometric characteristics between before and after a application of the program, and the percentage of body fat mass decreased significantly in the exercise group. The exercise group also showed a significant decrease in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol levels. In particular, the change in triglyceride levels after application of the program was approximately 54.3 mg/dl (range from 171.9 mg/dl pre-exercise to 117.6 mg/dl post-exercise). Basal physical fitness improved markedly among the exercise group participants. On the other hand, in the control group, with no application of a regular physical activity program, the body fat mass and the of LDL-cholesterol levels slightly increased after 12 weeks. Additionally, sarcopenia was seen to have significantly decreased after physical activity programs.
    Conclusion: The elderly women undergoing a regular exercise program showed improvement across several health indices through reduction in hyperlipidemia, hypercholesterolemia, and sarcopenia, leading to improved physical fitness. Further studies that consider psychosocial factors and nutrition status should be undertaken to increase the effectiveness of the regular physical activity program applied in this study.
  • 2.
  • Hypertension and cardiovascular disease due to high blood pressure are leading causes of death worldwide. Korea is rapidly becoming an aging society, and prevalence of hypertension is also increasing. Hypertension is usually defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg, or on the basis of current prescription of antihypertensive agents. According to the National Health and Nutrition Examination Survey (NHANES) in 2016, 29.1% (35.0% men, 22.9% women) of adults ≥ 30 years of age had hypertension. Although the awareness, treatment, and control rates for hypertension have steadily increased due to efforts by the government and the Korean Society of Hypertension, the control rate for hypertension remains less than 50%. In November 2017, the American Heart Association (AHA) presented a new standard for hypertension criteria (SBP/DBP ≥ 130/80 mmHg) based on the results of many clinical trials, including the Systolic Blood Pressure Intervention Trial (SPRINT), and recommended control rate of < 130/80 mmHg in hypertensive patients at high risk of cardiovascular disease. However, since the SPRINT included only 2% of those of Asian ethnicity and did not include patients with diabetes, stroke, and heart failure, it may be difficult to apply the new guideline to all high-risk hypertensive patients directly. Therefore, the government and related societies need to undertake further research to develop a Korean model for predicting the risk of incident cardiovascular disease; they also need to conduct research on the development of appropriate criteria for diagnosing hypertension in Koreans through clinical intervention studies involving high-risk patients. In addition, the Korea Centers for Disease Control and Prevention (KCDC) plans to more actively promote the impor tance of hyper tension prevention and management through a campaign to prevent hypertension.
  • 3.
  • 4.
  • Background: Age at natural menopause (ANM) is an important indicator of health issues in older women and is associated with menopausal symptoms, various chronic diseases and quality of life. However, research on the trends and influencing factors of ANM is insufficient. Therefore, in this study, we sought to identify such trends and the lifestyle factors influencing ANM.
    Methods/Results: Totally 12,761 natural menopausal women were selected from the Korea National Health and Nutrition Examination Survey (2001-2014). The mean±standard error of their ANM was 49.3±0.1 years. ANM was found to be associated with birth year, showing an upward trend of 0.73 years per five birth years. We evaluated the mean differences in ANM according to lifestyle factors, after adjusting for all confounders. The ANM of smokers was 0.55 years earlier, on average, than that of non-smokers (P = 0.024), and each 1 kg/m2 increase in body mass index (BMI) delayed ANM by 0.07 years (P < 0.001). It was found that ANM in women who had experienced childbirth was 1.59 years more than that of women with no childbirth experience (P < 0.001).
    Conclusion: As the life expectancy of women increases, there is greater emphasis on the importance of healthcare for older women. In this study, we found that the mean ANM is on the upward trend and smoking, body mass index, and prior childbirth are independently influencing ANM.
  • 5.
  • Emerging infectious diseases are becoming an even greater global public health threat due to the recent increase in population, urbanization, international trade, and travel. Subsequently, the public health of each country plays an important role in the global health security agenda. Considering that traditional indicator-based surveillance systems do not cover public health events that might turn into emergencies of international concern in time for an adequate response, eventbased surveillance systems need to be strengthened in each country. To facilitate an early, rapid response, the Korea Centers for Disease Control and Prevention collects information, every day from various sources, on events that have the potential to become public health threats and rapidly assesses them. The KCDC shares this information regularly with stakeholders in both public and private sectors.
  • 6.
  • 7.
  • Background: Vibrio vulnificus is a pathogenic bacterium naturally occurring in coastal and estuarine water worldwide that can cause life-threatening diseases by wound infection or food poisoning. The genetic background of V. vulnificus isolates thriving in Korea remains undefined.
    Methodology: In this study, 42 isolates (25 clinical and 17 environmental) were considered for examining their genetic relationship and diversity in Korea between 2014 and 2015. Multilocus sequence typing (MLST) method was used to study the prevalence and population structure of clinical strains. PCR conditions of the ten housekeeping genes and sequence type (ST) determination of all isolates were followed as described in PubMLST. Conventional PCR assay was performed to determine the presence of vvhA and rtxA genes and for 16S rRNA typing. Genetic diversity analysis was carried out using the MEGA 6 software. Based on the related STs, the isolates were analyzed by neighbor-joining method.
    Results: The 42 tested isolates belonged to 40 STs, each of which was new to the MLST database. The nucleotide diversity ranged from 0.017 (pntA) to 0.036 (lysA), and presented the largest number of variable sites (9.25%). Clinical and environmental (sea water) strains were distinguished by neighbor-joining tree constructed from STs.
    Conclusion: Forty-two V. vulnificus clinical isolates showed 40 different STs, which were stored in PubMLST as new STs, suggesting a high level of genetic diversity. These results revealed genetic differences between the clinical and environmental strains.
  • 8.
  • Asthma can be classified into heterogeneous groups with various pathophysiologies, and its course and prognosis may differ depending on phenotypes. However, there are no studies that reveal the clinical characteristics and natural course of asthma according to phenotypes. We have been conducting a nationwide pediatric asthma cohort study (Korean childhood Asthma Study, KAS) involving 20 hospitals since July 2016, for which a total of 473 children with asthma were recruited and are currently being tracked. Cluster analysis revealed four clusters (cluster 1: male-dominant atopic asthma; cluster 2: highly atopic asthma with atopic dermatitis; cluster 3: female-dominant, puberty-onset, atopic asthma; cluster 4: relatively nonatopic asthma). These childhood asthma clusters were determined by atopy, sex, puberty, and allergic comorbidities. It is necessary to clarify which clusters exacerbate or progress into uncontrolled asthma, how to prevent such an exacerbation, and how to effectively intervene in the progress of asthma, through longitudinal follow-up study.
  • 9.
  • [No Abstract Available]
  • 10.
  • This study reported the adsorption of Cu(II) ions onto activated carbon prepared from Myristica Fragrans shell (MFS AC) over independent variables of contact time, activating chemical (NaOH) concentration, initial adsorbate concentra- tion, initial pH of adsorbate solution and adsorption temperature. The MFS AC structure, morphology and total surface area were characterized by FTIR, SEM and BET techniques, respectively. The Cu(II) ions adsorption on the MFS AC (activated using 0.5 M NaOH) fitted best to Freundlich adsorption isotherm (FAI), and the FAI constant obtained was 0.845 L/g at 30 °C and pH 4.5. It followed the pseudo first order of adsorption kinetic (PFOAK) model, and the PFOAK based adsorption capac- ity was 107.65 mg/g. Thermodynamic study confirmed the Cu(II) ions adsorption should be exothermic and non-spontaneous process, physical adsorption should be taken place. The total surface area and pore volume based on BET analysis was 99.85 m2 /g and 0.086 cc/g, respectively.
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