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  • 국내학술논문 (290,385)
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  • 1.
  • Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) γ. Although TZDs are synthetic ligands for PPARγ, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated gluc
  • 2.
  • Background: This study aimed to investigate the association between the number of personal ties (the size of the socialsupport network) and the incidence of osteoporosis among older women in Korea.
    Methods/results: Data from 1,846 older women from the Korean Urban Rural Elderly Study were included in this study.Osteoporosis was diagnosed using the criteria of a t-score under –2.5. The social support network size was measuredthrough participants’ self-responses (number of confidants and spouse). The association between the social supportnetwork size and the incidence of osteoporosis was contingent on the average intimacy level of the social network. At thehighest average intimacy level, increasing the number of social support network members from one to six was associatedwith a linear decrease in the predicted probability of osteoporosis from 45% to 30%. However, at the lowest averageintimacy level, the predicted probability of osteoporosis dramatically increased from 48% to 80% as the
  • 3.
  • The national laboratory system is an integral part of the public health sector and performs important functions, such as laboratory-based tests for infectious diseases, to scientifically identify the causes of infectious diseases and respond swiftly. In Korea, infectious disease laboratories are designated by the Infectious Disease Control and Prevention Act, and each institute carries out its own role in infectious disease laboratory inspections. Institutions performing laboratory inspections are prescribed in the Infectious Disease Control and Prevention Act. Public institutions include the Korea Centers for Disease Control and Prevention (KCDC), National Quarantine Stations, Research Institutes of Public Health and Environment (RIPHEs), and Public Health Centers. Private institutions include clinics/ hospitals. Private institutions conduct their own inspections using in-vitro diagnostic medical devices licensed under the Medical Divices Act. Infectious diseases that cannot be examin
  • 4.
  • 5.
  • Mesoporous carbon‐based materials are attractive for energy storage devices. A novel multidimensional carbonaceous electrode material (hard carbon‐CNT, denoted as HC‐CNT) with the utilization of porous hard carbon as support was successfully synthesized in this work. Morphology of as‐obtained products was characterized by scanning electron microscopy (SEM), the phase was investigated by X‐ray diffraction (XRD), and the surface area was tested via Brunauer Emmett Teller (BET) method. The specific area of as‐synthesized HC‐CNT was up to 72.1 m²/g compared to hard carbon material (2.4 m²/g). The electrochemical characterization of HC‐CNT electrode was performed in a three‐electrode system. The results indicated great improvement in electrochemical performances for supercapacitors. The mass‐specific capacitance of HC‐CNT was 96.6 mF/cm² at the current density of 1.5 mA/cm², which was approximately two to three times larger than that of HCs. Furthermore, HC‐CNT electrode showed a lower inte
  • 6.
  • Purpose: Dehydration is a paediatric medical emergency but there is no single standard parameter to evaluate it at the emergency department. Our aim was to evaluate the reliability and validity of capillary refilling time as a triage parameter to assess dehydration in children.
    Methods: This was a prospective pilot cohort study of children who presented to two paediatric emergency departments in Italy, with symptoms of dehydration. Reliability was assessed by comparing the triage nurse’s measurements with those obtained by the physician. Validity was demonstrated by using 6 parameters suggestive of dehydration. Comparison between refilling time (RT) and a validated Clinical Dehydration Score (CDS) was also considered. The scale’s discriminative ability was evaluated for the outcome of starting intravenous rehydration therapy by using a receiver operating characteristic (ROC) curve.
    Results: Participants were 242 children. All nurses found easy to elicit the RT after being trained. Inte
  • 7.
  • Purpose: The objective of this study was to describe the clinical phenotypes of children and adolescents with cystic fibrosis (CF); and to assess the role of pancreatic insufficiency and neonatal screening in diagnosis.
    Methods: A cross-sectional study was conducted, which included 77 patients attending a reference center of CF between 2014 and 2016. Epidemiological data, anthropometric measurements, and the presence of pulmonary, pancreatic, gastrointestinal and hepatobiliary manifestations were evaluated based on clinical data and complementary examinations.
    Results: Of the 77 patients, 51.9% were male, with a median age of 147 months (7.0-297.0 months), and the majority showed adequate nutritional status. The most common phenotype was pulmonary (92.2%), followed by pancreatic (87.0%), with pancreatic insufficiency in most cases. Gastrointestinal manifestation occurred in 46.8%, with constipation being the more common factor. Hepatobiliary disease occurred in 62.3% of patients. The
  • 8.
  • Drug-induced autoimmune hepatitis (DIAIH) is an increasingly recognized form of drug-induced liver injury that leads to a condition similar to idiopathic autoimmune hepatitis. A number of drugs have been associated with DIAIH, minocycline is one of the most well characterized. Minocycline is a semisynthetic tetracycline antibiotic used in the treatment of acne vulgaris. Minocycline-induced autoimmune hepatitis presents with serologic and histologic features similar to idiopathic autoimmune hepatitis. However, the natural history and outcomes of these two conditions differ significantly. The majority of patients with minocycline-induced autoimmune hepatitis experience complete resolution of symptoms after withdrawal of the medication. Some patients may require a short course of steroids and rarely use of an immunomodulator to achieve resolution of disease. Recurrence of symptoms is rare and typically only occurs with reintroduction of minocycline. It is important for primary care provid
  • 9.
  • Accessory hepatic lobe is noted as and considered a rare disease in children. It can manifest with various symptoms and complications depending on the location, volume, type and position of the disease as presented on a child. The patient presented as a 14-month-old girl who was seen with a notable hepatosplenomegaly and portal hypertension. A diagnosis was made after taking an extensive medical history, observation and radiological examinations. The formal diagnosis was a prehepatic portal hypertension associated with accessory hepatic lobe.
  • 10.
  • During the cortical development, cells in the brain acquire somatic mutations that can be implicated in various neurodevelopmental disorders. There is increasing evidence that brain somatic mutations lead to sporadic form of epileptic disorders with previously unknown etiology. In particular, malformation of cortical developments (MCD), ganglioglioma (GG) associated with intractable epilepsy and non-lesional focal epilepsy (NLFE) are known to be attributable to brain somatic mutations in mTOR pathway genes and others. In order to identify such somatic mutations presenting as low-level in epileptic brain tissues, the mutated cells should be enriched and sequenced with high-depth coverage. Nevertheless, there are a lot of technical limitations to accurately detect low-level of somatic mutations. Also, it is important to validate whether identified somatic mutations are truly causative for epileptic seizures or not. Furthermore, it will be necessary to understand the molecular mechanism o
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